Pathogenetic aspects of the use of carnosine-containing drugs in the treatment of eye diseases caused by oxidative stress

Pathogenetic aspects of the use of carnosine-containing drugs in the treatment of eye diseases caused by oxidative stress
Goncharova N.A., Martynovskaya L.V., Pastukh I.V., Pastukh U.A.
Kharkiv Medical Academy of Postgraduate Education (Kharkiv, Ukraine)
Relevance. An imbalance between oxidants and antioxidants (oxidative stress) leads to numerous pathological changes in the body. An increase in the content of reactive oxygen species in organs and tissues is one of the main toxic factors in the development of most diseases of the organ of vision: cataracts, glaucoma, and various retinopathies. Therefore, the inclusion in the composition of medicinal ophthalmic preparations of those substances that are able to counteract free radicals and protect the eye tissue from damage to cellular lipid peroxidases is promising in the prevention and treatment of chronic eye diseases. Currently, in Ukraine, the drug Clarastil is successfully used, containing N-acetylcarnosine, which prevents oxidative stress, which can slow down the development of age-related cataracts.
Purpose. Study of the results of using the drug Clarastil in patients with early age-related cataract.
Material and methods. The study was conducted in a group of 24 patients with early age-related cataract (48 eyes) aged 50 to 65 years, who received Clarastil instillations twice a day for 6 months. Patients in this group led an active lifestyle and did not have severe concomitant diseases. Visual acuity ranged from 0.6 to 1.0 with correction. All patients underwent ophthalmological examinations every 2 months, including visometry, tonometry, biomicroscopy, and ophthalmoscopy.
Results. During the study, no eye deterioration was observed. Clarastil was well tolerated by all patients, providing a moisturizing effect on the conjunctiva. Visual acuity and the degree of lens opacity remained stable in 15 patients (30 eyes). An increase in visual acuity by 0.2 - 0.3 was observed in 7 subjects (14 eyes). In 2 patients (4 eyes), subcapsular opacities of the lenses significantly decreased, visual acuity increased to 1.0.
Conclusions. The use of the drug Clarastil in patients with age-related cataracts contributed to the stabilization and improvement of visual acuity, and a decrease in the manifestations of the dry eye syndrome. This allows Clarastil to be recommended for widespread use in patients with early age-related cataracts.
The work was published in the Materials of the scientific-practical conference with international participation "Filatov Readings - 2019", May 23-24, 2019 - Odessa: Chernomorye, 2019. - pp. 52-53.